Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling
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چکیده
منابع مشابه
Abietane-type diterpenoids from the roots of Salvia tebesana
Background and objectives: The genus Salvia is one of the largest genera in the family Lamiaceae and represents approximately 1000 species displaying a remarkable diversity.Salvia tebesana Bunge(Lamiaceae) is an endemic medicinal species that grows wild in center of Iran which is locally named “Maryamgoli Tabasi”. Methods: The dried r...
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From the aerial parts of Salvia ballotiflora, eleven diterpenoids were isolated; among them, four icetexanes and one abietane (1-5) are reported for the first time. Their structures were established by spectroscopic means, mainly ¹H- and 13C-NMR, including 1D and 2D homo- and hetero-nuclear experiments. Most of the isolated diterpenoids were tested for their antiproliferative, anti-inflammatory...
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BACKGROUND The genus Salvia is a rich source of structurally diverse terpenoids. Different species of the Salvia have been used in folk medicine of Iran and therefore attracted the attention of researchers for exploring their chemical constituents. In a project directed at structurally interesting bioactive metabolites from Iranian Lamiaceae, we studied Salvia rhytidea. RESULTS Fractionation ...
متن کاملTrypanocidal activity of abietane diterpenoids from the roots of Craniolaria annua.
A chloroform extract from roots of Craniolaria annua provided six new C-11 unsubstituted abietanes, 14-hydroxy-6,12-dione-7,9(11),13-abietatriene (1), 14-hydroxy-12-oxo-7,9(11),13-abietatriene (2), 6,12,14-trihydroxyabieta-5,8,11,13-tetraen-7-one (3), ar-abietatriene-12-ol-6,7-dione-14,16-oxide (4), ar-abietatriene-12,16-diol-14,16-oxide (5) and ar-abietatriene-12-ol-7-one-14,16-oxide (6), and ...
متن کاملCytotoxic and proapoptotic activity of diterpenoids from in vitro cultivated Salvia sclarea roots. Studies on the leukemia cell lines.
Four diterpenoids, ferruginol, salvipisone, aethiopinone and 1-oxoaethiopinone, were isolated from transformed roots of Salvia sclarea. Salvipisone and aethiopinone showed relatively high cytotoxicity against HL-60 and NALM-6 leukemia cells (IC50 range 0.6-7.7 microg/ mL which is equal to 2.0-24.7 microM), whereas 1-oxoaethiopinone and ferruginol were less active in this regard. Moreover, we ha...
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ژورنال
عنوان ژورنال: Revista Brasileira de Farmacognosia
سال: 2018
ISSN: 0102-695X
DOI: 10.1016/j.bjp.2017.11.007